Valacyclovir is an antiviral drug. It slows the growth and spread of the herpes virus to help the body fight the infection. Valacyclovir is used to treat infections caused by herpes viruses, including genital herpes, cold sores, and shingles (herpes zoster) in adults. Valacyclovir is used to treat cold sores in children who are at least 12 years old, or chickenpox in children who are at least 2 years old.

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Valacyclovir online prescription (1:1) and fluoroquinolones in patients with recurrent or chronic herpes simplex virus (HSV) infections. We evaluated the efficacy of oral fluoroquinolones to treat recurrent herpes simplex virus (HSV) infection in a large cohort of patients with HSV-1 or HSV-2 infection. Treatment was initiated within 2 weeks after an initial, negative evaluation and continued until disease progression, or a final evaluation. Patients were enrolled in a double-blind, randomized, parallel-group study. The primary efficacy endpoint was change from baseline in the frequency of symptoms as assessed by the HSV Prevalence and Severity Index (HSV-PVI). Secondary efficacy endpoints included the number of adverse events and the incidence of major adverse events. A total overstock drugstore free shipping code of 14,841 patients were included in the efficacy phase of study (5,069 women and 20,097 men), of whom 10,847 (56.7%) were HSV-2 patients. Of these, 6,835 (26.1%) were treated with oral fluoroquinolones, and 4,966 (24.5%) received placebo. Of the 4,816 (22.5%) patients treated with oral fluoroquinolones, 1.2% were discontinued because of adverse events, and the overall rates of adverse events were similar for the 2 groups. In the efficacy phase, there were no significant differences between the 2 treatment groups in any of the clinical endpoints measured, including number of new lesions or the HSV-PVI score ( ). The overall rate of infection was significantly higher among patients treated with oral fluoroquinolones (15.8%; 95% CI, 14.1%-16.7%) compared with placebo (4.0%; 95% CI, 3.7%-4.8%) ( ). During week 4, the rate at which HSV-PVI score was decreased significantly higher in the fluoroquinolone group (1.1%; 95% CI, 1.0%-1.3%) compared with the placebo group (0.8%; 95% CI, 0.7%-0.9%; P <.001). During the entire study, 3.6% of patients were in the placebo arm, whereas 13.5% of patients in the fluoroquinolone group were placebo arm. The percentage of patients in each arm who met the primary efficacy endpoint was similar (P =.58 for fluoroquinolones and P =.80 for placebo). Among patients given oral fluoroquinolones, 48.3% of patients were in the placebo arm, and 47.4% of patients in the fluoroquinolone arm met primary efficacy endpoint. The percentage of patients who were in the placebo arm who met secondary efficacy endpoint was similar (P =.54 for fluoroquinolones and P =.94 for placebo). The proportion of patients who had no disease (ie, "no disease" or with resolution") was similar in the 2 treatment groups (31.3% and 27.5%, respectively), the proportion who had a final outcome of "remission" was also similar for both groups (30.0% and 28.6%, respectively). The proportion of patients who were hospitalized was significantly higher in the fluoroquinolone group (30.8%; 95% CI, 29.0%-32.6%) compared with the placebo group (22.9%; 95% CI, 21.0%-24.1%) (P <.001). During weeks 12 through 18 of the study, proportion patients hospitalized was significantly higher in the fluoroquinolone group (34.2%; 95% CI, 30.7%-36.6%) compared with the placebo group (18.6%; 95% CI, 15.2%-19.2%; P <.001). During the efficacy phase, proportion of patients with a positive HSV-2 skin test was similar across all 3 arms of the study (29.9%, 29.2%, and 28.9%, respectively), the proportion was similar during weeks 12 through 18 (P =.82 for the 3 arms of study). HSV-2 skin test was negative in 7.3% of patients the oral fluoroquinolone arm, and 9.2% of patients in the placebo arm. During entire study, 5.9% of patients had a positive HSV-2 skin test. In the placebo arm, proportion of patients achieving a "remission" was significantly lower in the fluoroquinolone group (37.2%; 95% CI, 34.7%-39.4%) than in the placebo group (48.1%; 95% CI, 47.8%-49.1).



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